Notable individuals who have been diagnosed with ALS include:
- Baseball great Lou Gehrig
- Theoretical physicist, cosmologist and author Stephen Hawking
- Hall of Fame pitcher Jim "Catfish" Hunter
- U.S. Senator Jacob Javits
- Actor David Niven
- "SpongeBob SquarePants" creator Stephen Hillenburg
- “Sesame Street” creator Jon Stone
- Jazz musician Charles Mingus
- Singer/songwriter Kim Shattuck (The Muffs)
- Bassist Mike Porcaro (Toto)
- Musician Huddie Ledbetter (Lead Belly)
- Theatre producer Jenifer Estess
- Boxing champion Ezzard Charles
- NBA Hall of Fame basketball player George Yardley
- Golf caddie Bruce Edwards
- Photographer Eddie Adams
- Entertainer Dennis Day
- Former U.S. Vice President Henry A. Wallace
- U.S. Army General Maxwell Taylor
- NFL football player Steve Gleason
- NFL football player O.J. Brigance
- NFL football player Tim Shaw
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