Funding Opportunities for Researchers

We invest millions of dollars every year to support cutting-edge research across the translational pipeline from basic science to early-phase clinical trials as well as funding projects focused on other important areas, such as prevention, assistive technology, quality of care, workforce development and research infrastructure. 

Many of our awards are offered annually, but some are one-time only grants. All our programs require a letter of intent (LOI) followed by a full proposal (by invitation only). You can learn more on our Information for Applicants and Awardees page.

Our Requests for Applications

The Hoffman ALS Clinical Trial Awards Program

Description: This program supports early- to mid-stage (phase 1 or 2a) clinical trials of novel or repositioned therapeutics for ALS (either disease-modifying or symptomatic) or early trials testing imaging tracers in people living with ALS. This year, we are particularly interested in funding programs targeting TDP-43 and/or protein aggregation.
Funding: Up to $1,000,000 over two or three years 
Letter of Intent Due (CLOSED): November 26, 2024, 1:00 p.m. US ET
Full Proposal Due (by invitation only): February 25, 2025, 1:00 p.m. US ET

Learn About Our Awards and Programs

Additional Funding Opportunities

ALS Intermediate Patient Population Expanded Access (U01 Clinical Trial Required)

Funding Organization: National Institute of Neurological Disorders and Stroke (NINDS)
Description: This funding opportunity is intended to support scientific research utilizing data from expanded access studies for ALS using investigational drugs or biological products. Eligible applicants must be clinical trial sites that participate in a phase 3/efficacy clinical trial supported by a small business concern that is the FDA-designated sponsor of a drug or biological product which is the subject of an IND to prevent, diagnose, mitigate, treat, or cure ALS.
Available Funding: NINDS intends to commit up to $35,000,000 in FY2025 to fund two to five new awards contingent upon NIH appropriations and a sufficient number of meritorious applications.
Application Deadline: January 24, 2025

Want to add your funding opportunity to this list? Contact us at ResearchGrants@als.org.

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