Our Requests for Applications

Seed Grants 

Description: These grants fund preliminary ALS research that will support funding applications from other sources for larger scale and more impactful research projects. 
Funding: Up to $50,000 over 1 year
This opportunity has closed.

The Hoffman ALS Clinical Trial Awards Program 

Description: This program supports early- to mid-stage (phase 1 or 2a) interventional clinical trials of novel or repositioned therapeutics for ALS. 
Funding: Up to $1,000,000 over 2–3 years 
This opportunity has closed.

Milton Safenowitz Postdoctoral Fellowship Program

Description: This program supports the development of early career scientists by funding junior postdoctoral fellows doing research of high scientific merit and relevance to ALS. 
Funding: Up to $150,000 over 2 years 
This opportunity has closed. 

The Lawrence and Isabel Barnett Drug Development Program 

Description: This program supports the preclinical development of new or repurposed treatments for ALS. 
Funding: Up to $500,000 over 2 years 
This opportunity has closed.  

Learn About Our Awards and Programs

Additional Funding Opportunities 

Clinical Trials Addressing Unmet Needs of Rare Neurodegenerative Diseases (R01) Clinical Trials Required

Funding Organization: U.S. Food and Drug Administration 
Description: The purpose of this opportunity is to fund clinical trials evaluating efficacy and/or safety of products in support of a new indication or change in labeling to address unmet needs in rare neurodegenerative diseases.
Available Funding: Up to $650,000 per year for a maximum of four years; applicants may request up to an additional $250,000 total costs per year (to a maximum total award cost of $900,000 per year) for innovative and efficient trial approaches.
Application Deadline: October 22, 2024, 11:59 p.m. ET 

Clinical Studies of Orphan Products Addressing Unmet Needs of Rare Diseases (R01) 

Funding Organizations: U.S. Food and Drug Administration (FDA) 
Description: The purpose of this opportunity is to fund clinical trials (Phase 1, 2, and/or 3) of products evaluating efficacy and/or safety in support of a new indication or change in labeling to address unmet needs in rare diseases or conditions.
Available Funding: Up to $650,000 per year for up to four years; applicants may request up to an additional $250,000 total costs per year (to a maximum total award cost of $900,000 per year) for innovative and efficient trial approaches.
Application Deadline: October 22, 2024, 11:59 p.m. ET 

Sheila Essey Award for ALS Research 

Funding Organizations: The ALS Association, American Academy of Neurology, and American Brain Foundation 
Description: This award recognizes an individual who has made significant research contributions in the search for the cause, prevention of, and cure for ALS. The criteria being used to determine the recipient include recent major scientific impact, long-term scientific impact, and overall impact to ALS.
Prize: $50,000 to continue ALS research and complimentary registration for the American Academy of Neurology’s 2025 Annual Meeting
Application Deadline: October 31, 2024, 11:59 p.m. CT 

Want to add your funding opportunity to this list? Contact us at ResearchGrants@als.org.